angiotensin

noun

an·​gio·​ten·​sin ˌan-jē-ō-ˈten(t)-sən How to pronounce angiotensin (audio)
: either of two forms of a kinin of which one has marked vasoconstrictive action
also : a synthetic amide derivative of the physiologically active form used to treat some forms of hypotension

Examples of angiotensin in a Sentence

Recent Examples on the Web
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As a result, high-sodium vegetable juices may reduce the benefits conferred by medications like diuretics, ACE inhibitors, and angiotensin receptor blockers (ARBs). Julia Ries Wexler, Health, 4 Feb. 2026 There are several medications that can help, including beta-blockers, ACE inhibitors and angiotensin receptor blockers which also help lower blood pressure. Allison Aubrey, NPR, 2 Feb. 2026 Disruption of the kidneys’ renin-angiotensin system—named for the hormones involved, which regulate blood pressure—also interferes with insulin signaling. Jyoti Madhusoodanan, Scientific American, 16 Dec. 2025 One reason why this effect may happen is because compounds in miso may inhibit angiotensin-converting enzyme (commonly known as ACE) activity, which plays a key role in regulating blood pressure. Lauren Manaker, SELF, 18 Nov. 2025 See All Example Sentences for angiotensin

Word History

Etymology

angiotonin, an earlier name for the substance (from angio- + Greek tónos "stretching, strain, tension," alluding to its pressor effect + -in entry 1) + hypertensin, a synonymous name, from hypertens(ion) + -in entry 1, after Spanish hipertensina — more at tone entry 1

Note: The term angiotonin was introduced by the American physiologist Irvine H. Page (1901-91) and biochemist Oscar M. Helmer in "A crystalline pressor substance (angiotonin) resulting from the reaction between renin and renin activator," Journal of Experimental Medicine, vol. 71, No. 1 (January 1, 1940), pp. 29-42. The etymology is stated explicitly: "For this substance we suggest the name 'angiotonin' [Greek ἀγγεῖον, blood vessel, + τόνος (τείνω), strain]" (p. 29). Spanish hipertensina was introduced by the Argentine physiologist Eduardo Braun-Menéndez (1903-59) and coworkers in "La sustancia hipertensora de la sangre del riñón isquemiado," Revista de la Sociedad Argentina de Biología, vol. 15 (1939), pp. 420-25. Page and Braun-Menéndez later agreed to merge the two synonymous names into angiotensin; see "Suggested Revision of Nomenclature—Angiotensin," Science, vol. 127, Issue 3292 (January 31, 1958), p. 242.

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of angiotensin was in 1958

Cite this Entry

“Angiotensin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/angiotensin. Accessed 16 Feb. 2026.

Medical Definition

angiotensin

noun
an·​gio·​ten·​sin ˌan-jē-ō-ˈten(t)-sən How to pronounce angiotensin (audio)
1
: either of two forms of a kinin of which one has marked physiological activity and the other is its physiologically inactive precursor
especially : angiotensin ii
2
: a synthetic amide derivative of angiotensin II used to treat some forms of hypotension

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