an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
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Erica Sloan, SELF, 25 July 2025
Certain studies have found a slightly elevated risk of miscarriage associated with antidepressant use in pregnancy.
—Josh Feldman, NBC news, 22 July 2025
Alejandra Borunda, NPR, 30 July 2025
The current review found a total of 37 trials on St. John’s wort, with more showing effects against placebo than no effects, with similar or better results than antidepressants, Frost says.
—Tom Gavin, EverydayHealth.com, 28 July 2025
See All Example Sentences for antidepressant
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Adjective
These omegas are anti-inflammatory powerhouses, known to reduce body and brain inflammation through a bunch of different pathways that researchers suspect may have antidepressant effects.
—Erica Sloan, SELF, 25 July 2025
Certain studies have found a slightly elevated risk of miscarriage associated with antidepressant use in pregnancy.
—Josh Feldman, NBC news, 22 July 2025
Noun
But some classes of medications — from some beta blockers to diuretics to antidepressants — can affect the way people's bodies react to, or perceive, heat.
—Alejandra Borunda, NPR, 30 July 2025
The current review found a total of 37 trials on St. John’s wort, with more showing effects against placebo than no effects, with similar or better results than antidepressants, Frost says.
—Tom Gavin, EverydayHealth.com, 28 July 2025
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 4 Aug. 2025.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
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