antihistamine

noun

an·​ti·​his·​ta·​mine ˌan-tē-ˈhi-stə-ˌmēn How to pronounce antihistamine (audio)
-mən,
ˌan-tī-
: any of various compounds that counteract histamine in the body and that are used for treating allergic reactions (such as hay fever) and cold symptoms
antihistamine adjective
antihistaminic adjective or noun

Examples of antihistamine in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Antidepressants, blood pressure meds, antihistamines, and again, birth control can impact libido. Dominique Fluker, Essence, 5 Aug. 2025 Take an antihistamine before bedtime to alleviate a dry cough at night or in the early morning. Health Editorial Team, Health, 29 July 2025 Examples of these newer antihistamines include: Oral decongestants, such as pseudoephedrine, which is typically found behind the counter. Karen Berger, Verywell Health, 29 July 2025 It is also recommended to use either topical or oral antihistamines to reduce itching, such as hydrocortisone cream, calamine lotion, or an antihistamine gel (which reduces itching), as well as Benadryl or Claritin. Jenna Prestininzi, Freep.com, 15 July 2025 See All Example Sentences for antihistamine

Word History

First Known Use

1946, in the meaning defined above

Time Traveler
The first known use of antihistamine was in 1946

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Cite this Entry

“Antihistamine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antihistamine. Accessed 10 Aug. 2025.

Kids Definition

antihistamine

noun
an·​ti·​his·​ta·​mine ˌant-i-ˈhis-tə-ˌmēn How to pronounce antihistamine (audio)
-mən,
ˌan-ˌtī-
: any of various drugs used for treating allergic reactions and cold symptoms

Medical Definition

antihistamine

1 of 2 adjective
an·​ti·​his·​ta·​mine ˌant-i-ˈhis-tə-ˌmēn, ˌan-ˌtī-, -mən How to pronounce antihistamine (audio)
: tending to block or counteract the physiological action of histamine
human blood lacks antihistamine activity

antihistamine

2 of 2 noun
: any of various compounds that oppose the actions of histamine and are used especially for treating allergic reactions (as hay fever), cold symptoms, and motion sickness

More from Merriam-Webster on antihistamine

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