cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl How to pronounce cortisol (audio)
-ˌzȯl,
-ˌsōl,
-ˌzōl
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Feeling relaxed reduces the stress hormone cortisol, which can interrupt sleep. Kristen Rogers, CNN, 9 Mar. 2025 Chronic stress may negatively impact your immune system by increasing levels of the hormone cortisol and suppressing the immune system. Brittany Lubeck, Ms, Rdn, Verywell Health, 4 Mar. 2025 Sleeping issues: Your cortisol levels change throughout the day. Kirstyn Hill, Pharmd, Mph, Health, 3 Mar. 2025 That constant stress keeps cortisol levels elevated, worsening menopausal symptoms and increasing risks of hypertension, diabetes and heart disease. Dr. Kudzai Dombo, Flow Space, 26 Feb. 2025 See All Example Sentences for cortisol

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of cortisol was in 1951

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Cite this Entry

“Cortisol.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cortisol. Accessed 12 Mar. 2025.

Medical Definition

cortisol

noun
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

More from Merriam-Webster on cortisol

Last Updated: - Updated example sentences
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