cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl How to pronounce cortisol (audio)
-ˌzȯl,
-ˌsōl,
-ˌzōl
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Delights Woman Finds Cat 'Fast Asleep' on Her Bed, but There's Just One Problem Cats with lower testosterone and cortisol levels, for instance, were found to be more tolerant of other felines and even willing to share food. Thomas G. Moukawsher, MSNBC Newsweek, 25 Apr. 2025 Dancing reduces cortisol levels and releases oxytocin (the bonding hormone that is released when connecting with others), dopamine and endorphins. Rona Berg, Forbes.com, 24 Apr. 2025 Researchers have found elevated levels of cortisol, a stress hormone, in herds exposed to wolves. Jack Dolan, Los Angeles Times, 21 Apr. 2025 Unlike adrenaline’s quick action, cortisol plays a longer-term role in helping the body cope with sustained stress. Dr. Jamin Brahmbhatt, CNN Money, 16 Apr. 2025 See All Example Sentences for cortisol

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of cortisol was in 1951

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Cite this Entry

“Cortisol.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cortisol. Accessed 30 Apr. 2025.

Medical Definition

cortisol

noun
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

More from Merriam-Webster on cortisol

Last Updated: - Updated example sentences
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