endorphin

noun

en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (such as enkephalin) found especially in the brain that bind chiefly to opiate receptors and produce some pharmacological effects (such as pain relief) like those of opiates
specifically : beta-endorphin

Did you know?

The word endorphin was coined, back when the substances were discovered in the 1970s, by joining pieces of endogenous and morphine, morphine being a narcotic that closely resembles the endorphins and relieves pain in a similar way. Studies suggest that the pain-relieving practice called acupuncture works by releasing endorphins. Endorphins also seem to play an important role in pregnancy. Though much remains to be learned about the endorphins, the general public seems ready to give them credit for any all-natural high.

Examples of endorphin in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Dancing reduces cortisol levels and releases oxytocin (the bonding hormone that is released when connecting with others), dopamine and endorphins. Rona Berg, Forbes.com, 24 Apr. 2025 In addition, exposure to cold increases levels of endorphins, which are natural pain-relieving and mood-improving chemicals.5 Additional research could help apply these findings to how cold plunging may or may not relieve different types of pain and inflammation throughout the body. Cristina Mutchler, Verywell Health, 23 Apr. 2025 Time in nature An indoor, sedentary lifestyle does not increase endorphins and serotonin. Ana Morales, Vogue, 7 Apr. 2025 Plus, upbeat songs trigger the release of dopamine and endorphins, while dancing relieves physical tension—all of which can help counteract anxiety. Angela Haupt, TIME, 17 Jan. 2025 See All Example Sentences for endorphin

Word History

Etymology

International Scientific Vocabulary endogenous + morphine

First Known Use

1976, in the meaning defined above

Time Traveler
The first known use of endorphin was in 1976

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Cite this Entry

“Endorphin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/endorphin. Accessed 2 May. 2025.

Medical Definition

endorphin

noun
en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (as enkephalin and dynorphin) found especially in the brain that bind chiefly to opiate receptors and produce some of the same pharmacological effects (as pain relief) as those of opiates
specifically : beta-endorphin

More from Merriam-Webster on endorphin

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