fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil How to pronounce fentanyl (audio)
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
At 26 of those schools, nitazenes — a class of synthetic opioids, some of which are over 5 to 10 times more potent than fentanyl — were detected, according to DPS. Laura Bauer april 1, Kansas City Star, 1 Apr. 2026 Julia has reported on fentanyl in local schools, the aftermath of police shootings and crime trends in Charlotte. Patrick Wilson, Charlotte Observer, 31 Mar. 2026 He was accused of running a crew that dealt crack, powder cocaine, heroin and fentanyl throughout Jamaica, Queens. John Annese, New York Daily News, 29 Mar. 2026 That binding — along with effects similar to those of opioid drugs such as heroin, fentanyl or oxycodone — has led some experts and politicians to refer to kratom as an opioid. Kristen Rogers, CNN Money, 27 Mar. 2026 See All Example Sentences for fentanyl

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of fentanyl was in 1964

Browse Nearby Words

Cite this Entry

“Fentanyl.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fentanyl. Accessed 6 Apr. 2026.

Medical Definition

fentanyl

noun
fen·​ta·​nyl ˈfent-ᵊn-ˌil How to pronounce fentanyl (audio)
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.

More from Merriam-Webster on fentanyl

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

More from Merriam-Webster