: relating to, being, or causing physiological changes in the body (such as an increase in heart rate or dilation of bronchi) in response to stress
epinephrine is a fight-or-flight hormone
a fight-or-flight reaction

Examples of fight-or-flight in a Sentence

Recent Examples on the Web
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Instead of recognizing the tumor as an invader that needs to be destroyed, the brain processes the signal and activates the sympathetic nervous system, mainly known as the driver of the fight-or-flight response. Jacek Krywko, Scientific American, 4 Feb. 2026 Glenn described how adrenaline can hijack her system, pushing her into a constant fight-or-flight state. Marcus Thompson Ii, New York Times, 4 Feb. 2026 Neuroscience teaches us that under conditions of danger, the brain’s instinctive response is often to amplify the perception of threat as a default fight-or-flight mechanism for survival. Laurence Miller, Sun Sentinel, 14 Jan. 2026 Under chronic stress, however, the nervous system remains biased toward fight-or-flight, even when no immediate danger is present. Dana Santas, CNN Money, 14 Jan. 2026 See All Example Sentences for fight-or-flight

Word History

First Known Use

1973, in the meaning defined above

Time Traveler
The first known use of fight-or-flight was in 1973

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Cite this Entry

“Fight-or-flight.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fight-or-flight. Accessed 18 Feb. 2026.

Medical Definition

fight-or-flight

adjective
ˌfī-tər-ˈflīt
: relating to, being, or causing physiological changes in the body (such as an increase in heart rate or dilation of bronchi) in response to stress
the fight-or-flight response
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