: one haploid set of chromosomes with the genes they contain
broadly
: the genetic material of an organism compare proteome
Examples of genome in a Sentence
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The genome allows further investigation of Denisovan biological traits that may influence human health today.
—
Katie Hunt, CNN Money, 26 Dec. 2025
The flu genome is constantly undergoing minute changes that, cumulatively, can allow the virus to sidestep our preexisting immunity (the defenses established by past infections and vaccinations) as well as the protection offered by the annual flu shot.
—Lisa Jarvis, Mercury News, 23 Dec. 2025
These actions loosen up or batten down portions of the genome and are akin to opening or closing doors to specific genes.
—Ivan Amato, Quanta Magazine, 22 Dec. 2025
Fortunately, today, researchers explained that recent advancements in paleogenomics have permitted this cross-examination between modern genomes and ancient DNA, Archaeology Mag reports.
—Maria Mocerino, Interesting Engineering, 21 Dec. 2025
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Katie Hunt, CNN Money, 26 Dec. 2025
The flu genome is constantly undergoing minute changes that, cumulatively, can allow the virus to sidestep our preexisting immunity (the defenses established by past infections and vaccinations) as well as the protection offered by the annual flu shot.
—Lisa Jarvis, Mercury News, 23 Dec. 2025
These actions loosen up or batten down portions of the genome and are akin to opening or closing doors to specific genes.
—Ivan Amato, Quanta Magazine, 22 Dec. 2025
Fortunately, today, researchers explained that recent advancements in paleogenomics have permitted this cross-examination between modern genomes and ancient DNA, Archaeology Mag reports.
—Maria Mocerino, Interesting Engineering, 21 Dec. 2025
See All Example Sentences for genome
Cite this Entry
“Genome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genome. Accessed 31 Dec. 2025.
Copy CitationMedical Definition
genome
noun
ge·nome
ˈjē-ˌnōm 
: one haploid set of chromosomes with the genes they contain
broadly
: the genetic material of an organism
The idea behind sequencing an organism's genome—decoding, letter by letter, the message contained in every last one of its genes—is that it would tell us a lot about how the organism works. —Lori Oliwenstein, Discover
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