graft-versus-host disease

noun

graft-ver·​sus-host disease ˈgraft-ˌvər-səs-ˈhōst- How to pronounce graft-versus-host disease (audio)
: a potentially fatal bodily condition that results when T cells from a tissue or organ transplant and especially a bone marrow transplant react immunologically against the recipient's antigens attacking cells and tissues

Examples of graft-versus-host disease in a Sentence

Recent Examples on the Web
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But despite all precautions, in the 1990s, about a quarter of all patients died from infections and other complications, including graft-versus-host disease, in which transplanted immune cells attack the body’s own tissue. Caleb Hellerman, CNN Money, 5 June 2026 The biggest concern is that immune cells from his sister’s transplanted tissue are recognized as foreign and are attacked, which is known as graft-versus-host disease. Eric Branch, San Francisco Chronicle, 25 Feb. 2026 Over the years, the youngster has suffered from symptoms of graft-versus-host disease: scarring issues with his eyes, lung and liver disease, among others, his mother said. Lance Reynolds, Boston Herald, 7 Feb. 2026 The filing also cites several underlying medical problems that played a role in Escobedo’s decline, including sepsis, complications from graft-versus-host disease, a weakened immune system, chronic kidney impairment, and pneumonia, TMZ reported. Martha McHardy, MSNBC Newsweek, 15 Nov. 2025 See All Example Sentences for graft-versus-host disease

Word History

First Known Use

1965, in the meaning defined above

Time Traveler
The first known use of graft-versus-host disease was in 1965

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Cite this Entry

“Graft-versus-host disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/graft-versus-host%20disease. Accessed 17 Jun. 2026.

Medical Definition

graft-versus-host disease

noun
: a bodily condition that results when T cells from a usually allogeneic tissue or organ transplant and especially a bone marrow transplant react immunologically against the recipient's antigens attacking cells and tissues, that affects especially the skin, gastrointestinal tract, and liver with symptoms including skin rash, fever, diarrhea, liver dysfunction, abdominal pain, and anorexia, and that may be fatal
abbreviation GVHD

called also graft-versus-host reaction

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