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Because of this, vitamin D toxicity also results in hypercalcemia (blood calcium levels above normal) and hypercalciuria (excess calcium in the urine).—Jamie Johnson, Verywell Health, 29 Jan. 2026 According to Tan, hypercalcemia is riskiest for people with chronic kidney disease, which can affect the kidneys’ ability to convert vitamin D to calcitriol, as well as those who have difficulty absorbing the vitamin.—Julia Ries Wexler, Health, 28 Jan. 2026