1
: any of several diseases characterized by skin lesions
especially
: systemic lupus erythematosus sense 2
2
Lupus astronomy
: a southern constellation that is visible between the constellations of Scorpius and Centaurus and that is represented by the figure of a wolf
Above Lupus lies Scorpius, one of the few constellations whose star pattern actually suggests the object that it is named for. In the myths, the scorpion was assigned by Artemis, the hunting goddess, to kill Orion, far across the sky.—
Don Moser
Don MoserExamples of lupus in a Sentence
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Originally designed to target and wipe out cancer by reprogramming the patient’s immune cells, CAR T is now being offered to patients in hundreds of clinical trials for autoimmune conditions like multiple sclerosis, lupus, Graves’ disease, vasculitis, and many others.
—Amber Dance, ArsTechnica, 17 May 2026
The registry of ailments that are included in the bill was also expanded to include lupus, autism, Stage III HIV, severe Alzheimer's disease, and inflammatory bowel disease.
—Irene Wright, USA Today, 15 May 2026
There is no cure for lupus; its impact endurant.
—Literary Hub, 15 May 2026
Matlock is currently using the Saphnelo infusion, an intravenous mode of treating her lupus.
—Toria Sheffield, PEOPLE, 9 May 2026
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Amber Dance, ArsTechnica, 17 May 2026
The registry of ailments that are included in the bill was also expanded to include lupus, autism, Stage III HIV, severe Alzheimer's disease, and inflammatory bowel disease.
—Irene Wright, USA Today, 15 May 2026
There is no cure for lupus; its impact endurant.
—Literary Hub, 15 May 2026
Matlock is currently using the Saphnelo infusion, an intravenous mode of treating her lupus.
—Toria Sheffield, PEOPLE, 9 May 2026
See All Example Sentences for lupus
Cite this Entry
“Lupus.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/lupus. Accessed 21 May. 2026.
Copy CitationMedical Definition
lupus
noun
lu·pus
ˈlü-pəs 
: any of several diseases (as lupus vulgaris or systemic lupus erythematosus) characterized by skin lesions
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