macrophage

noun

mac·​ro·​phage ˈma-krə-ˌfāj How to pronounce macrophage (audio)
: a phagocytic tissue cell of the immune system that may be fixed or freely motile, is derived from a monocyte, functions in the destruction of foreign antigens (such as bacteria and viruses), and serves as an antigen-presenting cell compare histiocyte
macrophagic adjective

Examples of macrophage in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
By adding the donor’s own immune cells (macrophages) to the chip, the team watched the war unfold in real time. Mrigakshi Dixit, Interesting Engineering, 1 Jan. 2026 Curcumin works with cells in the immune system, such as macrophages and natural killer cells, to enhance the body's defense capabilities. Chelsea Rae Bourgeois, Health, 20 Dec. 2025 In the case of the influenza vaccine, the response is directed by dendritic cells, not by macrophages. Jay Kakade december 20, New Atlas, 20 Dec. 2025 After a skin injury, the researchers found that macrophages, a type of white blood cell, infiltrate dermal adipose tissue, a tissue found in the layers of the skin. Jasmine Laws, MSNBC Newsweek, 27 Oct. 2025 See All Example Sentences for macrophage

Word History

Etymology

borrowed from German Makrophagen (plural), from makro- macro- + -phagen, plural of -phage -phage

Note: Introduced, along with Mikrophagen "microphages," by Élie metchnikoff in "Ueber den Kampf der Zellen gegen Erysipelkokken," Archiv für pathologische Anatomie und Physiologie, Band 107 (1887), p. 222.

First Known Use

1887, in the meaning defined above

Time Traveler
The first known use of macrophage was in 1887

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Cite this Entry

“Macrophage.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/macrophage. Accessed 2 Jan. 2026.

Kids Definition

macrophage

noun
mac·​ro·​phage ˈmak-rə-ˌfāj How to pronounce macrophage (audio)
: a large phagocyte of the immune system

Medical Definition

macrophage

noun
mac·​ro·​phage ˈmak-rə-ˌfāj How to pronounce macrophage (audio) -ˌfäzh How to pronounce macrophage (audio)
: a phagocytic tissue cell of the immune system that may be fixed or freely motile, is derived from a monocyte, functions in the destruction of foreign antigens (as bacteria and viruses), and serves as an antigen-presenting cell see histiocyte, mononuclear phagocyte system
macrophagic adjective

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