naloxone

noun

nal·​ox·​one na-ˈläk-ˌsōn How to pronounce naloxone (audio)
: a synthetic potent antagonist of narcotic drugs (such as morphine and fentanyl) that is administered especially in the form of its hydrochloride C19H21NO4·HCl

Note: Naloxone is administered by injection or as a nasal spray to reverse the effects of opioids especially in the emergency treatment of opioid overdose. It is also administered in combination with buprenorphine in the form of a dissolvable tablet placed under the tongue or a film placed inside the cheek to treat opioid dependence.

Examples of naloxone in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Data also shows that Maryland's Overdose Response Programs distributed record amounts of drug test strips and naloxone, which is used to reverse the effects of opioid overdoses. Jt Moodee Lockman, CBS News, 30 Jan. 2026 The naloxone strengthened the man’s pulse and breathing, and his condition began to improve. Elissa Jorgensen, Dallas Morning News, 29 Jan. 2026 First responders treated Irsay with naloxone, a drug used to treat opioid overdoses, before transporting him to a local hospital, according to police reports. Zachary Folk, Forbes.com, 22 Jan. 2026 In Massachusetts, naloxone, known also by the name brand Narcan, is also available at pharmacies without a prescription. Colleen Cronin, Boston Herald, 21 Jan. 2026 See All Example Sentences for naloxone

Word History

Etymology

N-allyl + hydroxy- + -one

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of naloxone was in 1964

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Cite this Entry

“Naloxone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/naloxone. Accessed 4 Feb. 2026.

Medical Definition

naloxone

noun
: a potent synthetic antagonist of narcotic drugs (as morphine and fentanyl) that is administered especially in the form of its hydrochloride C19H21NO4·HCl

Note: Naloxone is administered by injection or as a nasal spray to reverse the effects of opioids and especially in the emergency treatment of opioid overdose. It is also administered in combination with buprenorphine in the form of a dissolvable tablet placed under the tongue or a film placed inside the cheek to treat opioid dependence. Trademarks for preparations containing naloxone include Bunavail, Evzio, Narcan, Suboxone, and Zubsolv.

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