nociceptive

adjective

no·​ci·​cep·​tive ˌnō-si-ˈsep-tiv How to pronounce nociceptive (audio)
1
of a stimulus : painful, injurious
2
: of, induced by, or responding to a nociceptive stimulus
nociceptive pain
a nociceptive nerve pathway

Examples of nociceptive in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Especially those parts of the brain associated with receiving nociceptive information. Joshua Rapp Learn, Discover Magazine, 30 Apr. 2025 Many chronic pain conditions actually involve a combination of all three of these phenomena – nociceptive, neuropathic and nociplastic pain – which adds to the difficulty of diagnosis and treatment. Rachael Rzasa Lynn, The Conversation, 25 July 2024 Specific substances in the body, such as prostaglandins (a group of lipid compounds with hormone-like effects), can also lower nociceptive thresholds. Jennifer Chesak, Verywell Health, 24 June 2024

Word History

Etymology

Latin nocēre "to injure, harm" + -i- + -ceptive (in receptive) — more at noxious

Note: Term probably introduced by the British physiologist Charles Scott Sherrington (1857-1952) in several publications in 1904, as "Correlation of Reflexes and the Principle of the Common Path" (opening address to a meeting of the British Association, Section I, Physiology), Nature, vol. 70, no. 1819 (September 8, 1904), p. 463.

First Known Use

1904, in the meaning defined at sense 1

Time Traveler
The first known use of nociceptive was in 1904

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Cite this Entry

“Nociceptive.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/nociceptive. Accessed 5 Jul. 2026.

Medical Definition

nociceptive

adjective
no·​ci·​cep·​tive ˌnō-si-ˈsep-tiv How to pronounce nociceptive (audio)
1
of a stimulus : painful, injurious
2
: of, induced by, or responding to a nociceptive stimulus
used especially of receptors or protective reflexes
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