polygenic

adjective

poly·​gen·​ic ˌpä-lē-ˈje-nik How to pronounce polygenic (audio) -ˈjē- How to pronounce polygenic (audio)
: of, relating to, mediated by, or constituting polygenes : involving two or more nonallelic genes collectively in determining inherited characteristics : multifactorial sense 1
polygenic inheritance
polygenic traits
Others think the allergic state is polygenic: transmitted by a number of genes whose combined expression is necessary to make a person allergic.Paul D. Buisseret

Examples of polygenic in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
But the clinical value of polygenic risk scores for even straightforward medical conditions like asthma and stroke remains highly dubious. Arthur Caplan & James Tabery, Scientific American, 28 July 2025 From the dataset, the researchers were able to create what’s known as a polygenic risk score, which takes into account which genetic variants a person has that have been linked to a higher BMI in adulthood. Kaitlin Sullivan, NBC news, 21 July 2025 This confirmed that obesity is highly polygenic, meaning more than a single gene plays some sort of role in the process. New Atlas, 21 July 2025 Most traits and diseases of interest are polygenic. Kermit Pattison, Scientific American, 20 May 2025 See All Example Sentences for polygenic

Word History

Etymology

poly- + gene + -ic entry 1, after German polygen

Note: The term polygen was introduced by the German zoologist and social Darwinist Ludwig Plate (1862-1937) in Vererbungslehre, mit besonderer Berücksichtigung des Menschen (Leipzig, 1913), p. 75

First Known Use

1928, in the meaning defined above

Time Traveler
The first known use of polygenic was in 1928

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Cite this Entry

“Polygenic.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/polygenic. Accessed 3 Aug. 2025.

Medical Definition

polygenic

adjective
poly·​gen·​ic ˌpäl-i-ˈjēn-ik How to pronounce polygenic (audio) -ˈjen-ik How to pronounce polygenic (audio)
: of, relating to, or resulting from polygenes : multifactorial
a polygenic disorder
polygenically adverb
Last Updated: - Updated example sentences
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