: either of two physiologically active isomers C21H30O2 from hemp plant resin
especially : one that is the chief intoxicant in marijuana
When a person tokes, eats or vapes cannabis, a wave of THC, or tetrahydrocannabinol, washes into the brain. Laura Sanders
THC, the main chemical component of marijuana, has been shown to reduce nausea and increase appetite in chemotherapy patients. Andrew Weil
THC disappears from blood quickly as it is absorbed in the brain, making blood tests a more reliable measure of recent use but not a great correlate of impairment. Eliza Gray

Examples of THC in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
As the legislation did not put limitations on other variants of THC, the farm bill definition led to an unintended loophole that allowed businesses to create products that meet the legal THC percentage threshold but still create products that include enough THC to get people high. Molly Parks, The Washington Examiner, 27 Dec. 2025 When the two students were in the bathroom, an argument allegedly ensued about a THC vape pen Matthews accused Meismer of stealing, prosecutors said, ABC 13 reports. Kc Baker, PEOPLE, 22 Dec. 2025 In 2025, dispensaries regularly stock joints that have more than 35 percent THC. Nicholas Florko, The Atlantic, 19 Dec. 2025 The biggest factor in the difference is the amount of THC found in something. Joyce Orlando, Nashville Tennessean, 18 Dec. 2025 See All Example Sentences for THC

Word History

Etymology

tetrahydrocannabinol

First Known Use

1967, in the meaning defined above

Time Traveler
The first known use of THC was in 1967

Browse Nearby Words

Cite this Entry

“THC.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/THC. Accessed 2 Jan. 2026.

Medical Definition

: either of two physiologically active isomers C21H30O2 that occur naturally in hemp plant resin or are synthetically prepared:
a
: one that is the chief intoxicant in marijuana and is used medicinally

called also delta-9-tetrahydrocannabinol, delta-9-THC

see dronabinol
b
: one that is present in marijuana only in minute quantities

More from Merriam-Webster on THC

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