amyotrophic lateral sclerosis

noun

amyo·​tro·​phic lateral sclerosis ˌā-ˌmī-ə-ˈtrō-fik- How to pronounce amyotrophic lateral sclerosis (audio) -ˈträ- How to pronounce amyotrophic lateral sclerosis (audio)
: a rare progressive degenerative fatal disease affecting the motor neurons, usually beginning in middle age, and characterized especially by increasing and spreading muscular weakness and atrophy
abbreviation ALS

called also Lou Gehrig's disease

Examples of amyotrophic lateral sclerosis in a Sentence

Recent Examples on the Web
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The goal was to raise awareness for amyotrophic lateral sclerosis (ALS), a rare degenerative disease that causes progressive paralysis of the muscles. Zoey Lyttle, People.com, 25 Apr. 2025 Eric Dane, whose many TV credits include Grey’s Anatomy, The Last Ship and Euphoria, has been diagnosed with ALS (amyotrophic lateral sclerosis aka Lou Gehrig’s disease). Matt Webb Mitovich, TVLine, 10 Apr. 2025 Hawking began his research career in the 1960s, well before his diagnosis with ALS (amyotrophic lateral sclerosis) led him to use a wheelchair and communicate through technology rather than his voice for most of his adult life. Paul Sutter, Space.com, 19 Mar. 2025 The program funds research into amyotrophic lateral sclerosis (ALS), traumatic brain injuries (TBI), and epilepsy. Emily Kay Votruba, EverydayHealth.com, 11 Apr. 2025 See All Example Sentences for amyotrophic lateral sclerosis

Word History

Etymology

a- entry 2 + my- + -trophic

First Known Use

1875, in the meaning defined above

Time Traveler
The first known use of amyotrophic lateral sclerosis was in 1875

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Cite this Entry

“Amyotrophic lateral sclerosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/amyotrophic%20lateral%20sclerosis. Accessed 3 May. 2025.

Medical Definition

amyotrophic lateral sclerosis

noun
: a rare fatal progressive degenerative disease that affects pyramidal motor neurons, usually begins in middle age, and is characterized especially by increasing and spreading muscular weakness
abbreviation ALS

called also Lou Gehrig's disease

More from Merriam-Webster on amyotrophic lateral sclerosis

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