cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl How to pronounce cortisol (audio)
-ˌzȯl,
-ˌsōl,
-ˌzōl
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
One recent study performed in mice found that removing a stress hormone (the equivalent of cortisol in humans) triggered rapid hair growth cycles, regardless of factors like aging. Cristina Mutchler, Health, 30 Jan. 2025 Another 2021 study found that sleep deprivation increased levels of cortisol during interpersonal conflict. Daisy Jones, Vogue, 26 Jan. 2025 Chronic stress, when the sympathetic nervous system doesn’t have a chance to release control, stimulates cortisol production. Shani Harmon, Forbes, 23 Jan. 2025 According to health system Piedmont Healthcare, practicing hygge can lower the adrenal stress response and lessen cortisol spikes. Sarah Buder, AFAR Media, 20 Jan. 2025 See all Example Sentences for cortisol 

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of cortisol was in 1951

Dictionary Entries Near cortisol

Cite this Entry

“Cortisol.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cortisol. Accessed 11 Feb. 2025.

Medical Definition

cortisol

noun
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

More from Merriam-Webster on cortisol

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!