diphenhydramine
noun
di·phen·hy·dra·mine
ˌdī-ˌfen-ˈhī-drə-ˌmēn 
: an antihistamine C17H21NO used especially in the form of its hydrochloride
Examples of diphenhydramine in a Sentence
Recent Examples on the Web
The American Pharmacists Association says patients should use caution with combination cough and cold products that contain diphenhydramine.
—
Asuka Koda, CNN Money, 1 Aug. 2025
Consumers who have medical concerns or questions about diphenhydramine should contact their health care professional.
—Cara Lynn Shultz, People.com, 16 July 2025
An autopsy showed the 6-month-old had antihistamine diphenhydramine, commonly found in medications like Benadryl, at levels nearly three times the amount for an adult in her system, police said.
—Craig Shoup, Nashville Tennessean, 26 Mar. 2025
Anticholinergics are used to reduce cold and flu symptoms (diphenhydramine/Benadryl), relieve motion sickness and histamine reactions (promethazine/Phenergan) and relax the bladder to limit frequent urination (oxybutynin/Ditropan).
—New Atlas, 11 July 2025
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Asuka Koda, CNN Money, 1 Aug. 2025
Consumers who have medical concerns or questions about diphenhydramine should contact their health care professional.
—Cara Lynn Shultz, People.com, 16 July 2025
An autopsy showed the 6-month-old had antihistamine diphenhydramine, commonly found in medications like Benadryl, at levels nearly three times the amount for an adult in her system, police said.
—Craig Shoup, Nashville Tennessean, 26 Mar. 2025
Anticholinergics are used to reduce cold and flu symptoms (diphenhydramine/Benadryl), relieve motion sickness and histamine reactions (promethazine/Phenergan) and relax the bladder to limit frequent urination (oxybutynin/Ditropan).
—New Atlas, 11 July 2025
See All Example Sentences for diphenhydramine
Cite this Entry
“Diphenhydramine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/diphenhydramine. Accessed 7 Aug. 2025.
Copy CitationMedical Definition
diphenhydramine
noun
di·phen·hy·dra·mine
ˌdī-ˌfen-ˈhī-drə-ˌmēn
: an antihistamine used especially in the form of its hydrochloride C17H21NO·HCl to treat allergy symptoms and motion sickness and to induce sleep see benadryl
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