1
: any of several diseases characterized by skin lesions
especially
: systemic lupus erythematosus sense 2
2
Lupus astronomy
: a southern constellation that is visible between the constellations of Scorpius and Centaurus and that is represented by the figure of a wolf
Above Lupus lies Scorpius, one of the few constellations whose star pattern actually suggests the object that it is named for. In the myths, the scorpion was assigned by Artemis, the hunting goddess, to kill Orion, far across the sky.—Don Moser
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“Lupus.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/lupus. Accessed 14 Jul. 2026.
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