Synonyms of first-linenext
: being the preferred, standard, or first choice
first-line treatment of tuberculosis
compare second-line

Examples of first-line in a Sentence

surgery is usually not considered a first-line treatment for this type of cancer
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Nelson's grandfather, Bill Christian, and great uncle, Roger Christian, were first-line forwards on the 1960 squad that beat the Soviet Union and Canada to take the title in Squaw Valley, California. CBS News, 6 Feb. 2026 Nelson’s grandfather, Bill Christian, and great uncle, Roger Christian, were first-line forwards on the 1960 squad that beat the Soviet Union and Canada to take the title in Squaw Valley, California. Dave Campbell, Chicago Tribune, 6 Feb. 2026 Britta Curl-Salemme was also moved up to the second line with Minnesota Frost teammate Taylor Heise and Abbey Murphy, while Janecke moved from first-line left wing to fourth-line center. Michael Russo, New York Times, 5 Feb. 2026 Standard treatments for sleep apnea The standard first-line treatment for OSA is a continuous positive airway pressure (CPAP) machine, which uses a mask to deliver pressurized air that keeps the airway open during sleep. Shiv Sudhakar, FOXNews.com, 23 Jan. 2026 See All Example Sentences for first-line

Word History

First Known Use

1919, in the meaning defined above

Time Traveler
The first known use of first-line was in 1919

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Cite this Entry

“First-line.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/first-line. Accessed 15 Feb. 2026.

Medical Definition

first-line

adjective
: being the preferred, standard, or first choice
first-line treatment of advanced breast cancer
compare second-line
Last Updated: - Updated example sentences
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