melatonin

noun

mel·​a·​to·​nin ˌme-lə-ˈtō-nən How to pronounce melatonin (audio)
: a vertebrate hormone that is derived from serotonin, is secreted by the pineal gland especially in response to darkness, and has been linked to the regulation of circadian rhythms

Examples of melatonin in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Keep the bedroom dark by using blackout shades or curtains to promote melatonin production. Cristina Mutchler, Verywell Health, 20 Sep. 2025 For a better night’s sleep, Palinski-Wade recommends reaching for melatonin-rich foods such as tart cherries, pistachios and Greek yogurt before bedtime. Mariette Williams, USA Today, 18 Sep. 2025 Police said no children became seriously ill, but said that the melatonin posed serious health risks. Emma Bussey, FOXNews.com, 18 Sep. 2025 Disruptive blue wavelengths can wreak havoc on the body’s internal clock, even suppressing the production of melatonin—a hormone that helps regulate our circadian rhythm. Laura Kiniry, Popular Science, 17 Sep. 2025 See All Example Sentences for melatonin

Word History

Etymology

mela-, extracted from Greek melan-, mélās "black, dark" + -tonin (in serotonin); so named because the hormone can lighten skin color in animals by reversing the effect of melanocyte-stimulating hormones — more at melano-

Note: The word was probably introduced in the first published description of the hormone's isolation: Aaron B. Lerner, et al., "Isolation of melatonin, the pineal gland factor that lightens melanocytes," Journal of the American Chemical Society, vol. 80, no. 10 (May 20, 1958), p. 2587.

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of melatonin was in 1958

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Cite this Entry

“Melatonin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/melatonin. Accessed 22 Sep. 2025.

Kids Definition

melatonin

noun
mel·​a·​to·​nin ˌmel-ə-ˈtō-nən How to pronounce melatonin (audio)
: a hormone that is secreted by the pineal gland especially in response to darkness and has been linked to the regulation of bodily functions or activities (as sleep) that occur in approximately 24 hour cycles

Medical Definition

melatonin

noun
mel·​a·​to·​nin ˌmel-ə-ˈtō-nən How to pronounce melatonin (audio)
: a vertebrate hormone C13H16N2O2 that is derived from serotonin, is secreted by the pineal gland especially in response to darkness, and has been linked to the regulation of circadian rhythms

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