progesterone

noun

pro·​ges·​ter·​one prō-ˈje-stə-ˌrōn How to pronounce progesterone (audio)
: a female steroid sex hormone C21H30O2 that is secreted by the corpus luteum to prepare the endometrium for implantation and later by the placenta during pregnancy to prevent rejection of the developing embryo or fetus
also : a synthetic steroid resembling progesterone in action

Examples of progesterone in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
The monthly injections stop her body’s production of estrogen and progesterone. Kayla Grant, People.com, 29 July 2025 Rising progesterone levels prompt your uterine lining to thicken. Laura Dorwart, Verywell Health, 8 July 2025 After pregnancy, progesterone levels nosedive, which can drain your energy levels and mental health. Julia Ries, SELF, 23 June 2025 This may happen due to hormonal issues, such as low progesterone, or problems with the way your endometrium (uterine lining) responds to progesterone. Laura Dorwart, Verywell Health, 8 July 2025 See All Example Sentences for progesterone

Word History

Etymology

blend of progestin and luteosterone (borrowed from German Luteosteron, from luteo- luteo- + -steron -sterone), both earlier names for progesterone

Note: The name resulted from a compromise between researchers associated with the earlier names, the American gynecologist Willard M. Allen and embryologist George Washington Corner, and the German biochemists Adolph Butenandt and Karl Heinrich Slotta. See W. M. Allen, A. Butenandt, G. W. Corner, and K. H. Slotta, "Nomenclature of Corpus Luteum Hormone," Nature, vol. 136, number 303 (September 1, 1935), p. 303.

First Known Use

1935, in the meaning defined above

Time Traveler
The first known use of progesterone was in 1935

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Cite this Entry

“Progesterone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/progesterone. Accessed 5 Aug. 2025.

Kids Definition

progesterone

noun
pro·​ges·​ter·​one prō-ˈjes-tə-ˌrōn How to pronounce progesterone (audio)
: a hormone that is produced by the corpus luteum and causes the uterus to change so that it provides a suitable environment for a fertilized egg

Medical Definition

progesterone

noun
pro·​ges·​ter·​one prō-ˈjes-tə-ˌrōn How to pronounce progesterone (audio)
: a female steroid sex hormone C21H30O2 that is secreted by the corpus luteum to prepare the endometrium for implantation and later by the placenta during pregnancy to prevent rejection of the developing embryo or fetus
also : a synthetic steroid resembling progesterone in action

More from Merriam-Webster on progesterone

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