progesterone

noun

pro·​ges·​ter·​one prō-ˈje-stə-ˌrōn How to pronounce progesterone (audio)
: a female steroid sex hormone C21H30O2 that is secreted by the corpus luteum to prepare the endometrium for implantation and later by the placenta during pregnancy to prevent rejection of the developing embryo or fetus

Examples of progesterone in a Sentence

Recent Examples on the Web
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According to the outlet, Howlett said she and Julie Howlett had been married for four years and were both transitioning to female while taking estrogen and progesterone. Stepheny Price, FOXNews.com, 2 July 2026 Another option is switching to a medication that contains progestin, a synthetic form of progesterone. Cathy Nelson, Health, 1 July 2026 The theory is that this combination may help keep histamine in check, basically replacing the effect of progesterone. Theara Coleman, TheWeek, 1 July 2026 Wurth saw two more physicians who refused to discuss hormones before a urologist started her on estrogen gel, oral progesterone and a vaginal estrogen cream. Laura Trujillo, USA Today, 30 June 2026 See All Example Sentences for progesterone

Word History

Etymology

blend of progestin and luteosterone (borrowed from German Luteosteron, from luteo- luteo- + -steron -sterone), both earlier names for progesterone

Note: The name resulted from a compromise between researchers associated with the earlier names, the American gynecologist Willard M. Allen and embryologist George Washington Corner, and the German biochemists Adolph Butenandt and Karl Heinrich Slotta. See W. M. Allen, A. Butenandt, G. W. Corner, and K. H. Slotta, "Nomenclature of Corpus Luteum Hormone," Nature, vol. 136, number 303 (September 1, 1935), p. 303.

First Known Use

1935, in the meaning defined above

Time Traveler
The first known use of progesterone was in 1935

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Cite this Entry

“Progesterone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/progesterone. Accessed 6 Jul. 2026.

Kids Definition

progesterone

noun
pro·​ges·​ter·​one prō-ˈjes-tə-ˌrōn How to pronounce progesterone (audio)
: a hormone that is produced by the corpus luteum and causes the uterus to change so that it provides a suitable environment for a fertilized egg

Medical Definition

progesterone

noun
pro·​ges·​ter·​one prō-ˈjes-tə-ˌrōn How to pronounce progesterone (audio)
: a female steroid sex hormone C21H30O2 that is secreted by the corpus luteum to prepare the endometrium for implantation and later by the placenta during pregnancy to prevent rejection of the developing embryo or fetus

Note: Synthetic steroids (such as progestins) that function similarly in the body are sometimes also referred to as progesterones.

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